A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes
Eli Lilly and Company
Summary
The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Have Body Mass Index (BMI) at screening of the following: * 30 kilogram per square meter (kg/m2) OR * 27 kg/m2 with at least one of the following weight-related health conditions at screening: * high blood pressure * dyslipidemia * obstructive sleep apnea, or * heart disease * Have a stable body weight (\<5% body weight change) for 90 days prior to screening. * Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cry…
Interventions
- DrugEloralintide
Administered SC
- DrugPlacebo
Administered SC
Locations (173)
- MFA Clinical ResearchTuscaloosa, Alabama
- Headlands Research - ScottsdaleScottsdale, Arizona
- Neighborhood Healthcare Institute of HealthEscondido, California
- Ark Clinical Research - Fountain ValleyFountain Valley, California
- Desert Oasis Healthcare Medical GroupPalm Springs, California
- Peninsula Research AssociatesRolling Hills Estates, California