Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease: OPTIMIZE ASCVD
Colorado Prevention Center
Summary
This is a randomized, controlled, collaborative, multicenter, pilot implementation science study evaluating the hypothesis that algorithm- and multi-professional team-supported lipid management reduces low density lipoprotein-cholesterol (LDL-C) compared with usual care in patients with atherosclerotic cardiovascular disease (ASCVD).
Description
OPTIMIZE-ASCVD is a randomized, controlled, collaborative, open-label, multicenter pilot implementation science study evaluating the hypothesis that algorithm- (Appendix A) and multi-professional team-supported lipid management reduces LDL-C compared with usual care in patients with ASCVD. Approximately 100 participants will be randomized (1:1). * Participant preference for injectable vs oral lipid therapy will be recorded at baseline. * Participants allocated to algorithm-and multi-professional team-supported lipid management will be evaluated by a physician and prescribed lipid therapy whi…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Provided informed consent * Age \>18 years inclusive at screening * Documented atherosclerotic vascular disease including: * Coronary artery disease (prior revascularization, myocardial infarction, imaging evidence of coronary atherosclerosis) * Peripheral artery disease (prior revascularization, amputation, ankle: brachial index (ABI) ≤ 0.90, imaging evidence of extra-coronary atherosclerosis) * Carotid artery disease (prior endarterectomy or stenting of the extracranial carotid artery or imaging evidence of carotid atherosclerosis) * Imaging evidence of athero…
Interventions
- OtherAlgorithm- and multi-professional team-supported lipid management
Algorithm- and multi-professional team-supported lipid management
- OtherGuideline-directed lipid management by usual care provider
Guideline-directed lipid management by usual care provider
Location
- University of Colorado Health System (UCHealth)Aurora, Colorado