NYU Langone Health
The overarching objective is to examine the brain-based biological mechanistic pathway by which exercise exerts anxiolytic effects. The investigators will measure brain-derived markers of mitochondrial metabolism (acetyl-L-carnitine \[LAC\]) and inflammation (interleukin-6 \[IL-6\]) using innovative technology to isolate neuronal exosomes.
Inclusion Criteria: For both participant groups: To be eligible to participate in this study, an individual must meet all of the following criteria: * Between 18-50 years of age * Currently sedentary (≤60 minutes of moderate intensity exercise per week for the past 3 months) * Capable and willing to provide informed consent For anxiety disorder participant group, an individual must also meet: • Primary psychiatric diagnosis of generalized anxiety disorder (GAD), social anxiety disorder, or panic disorder Exclusion Criteria: * Lifetime history of Bipolar I or II or any psychotic disorder…
Exercise intervention is delivered in weekly individual sessions virtually for the 4-week intervention period. Sessions range from 25-45 minutes. The sessions serve as touch base points to review exercise for the week, plan for the coming week, problem-solve obstacles, and discuss various motivational strategies to help with an exercise routine. Participants are prescribed 150 minutes of moderate intensity exercise per week to be completed at home.
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