Carilion Clinic
This study is an invite only study looking at the effects of Low-Intensity Focused Ultrasound (LIFU) on epilepsy patients with implanted electrodes under the care of Dr. Shah.
This project will explore the use of Low-Intensity Focused Ultrasound (LIFU) as a non-invasive method to reduce seizures and potentially enhance cognitive functions in epilepsy patients. LIFU can target specific deep brain areas without surgery, offering an alternative to invasive procedures. The study focuses on patients who have an implanted Responsive Neurostimulation System (RNS). LIFU will be used to stimulate the entorhinal cortex, a brain region involved in both seizure activity and memory formation. Investigators are targeting the perforant pathway from EC to hippocampus, which primari…
Inclusion Criteria: * Diagnosis of medically refractory focal epilepsy of mesial temporal onset * RNS system implantation in the hippocampus * Prior MRI and CT of the head * Able to consent for themselves * Internet access Exclusion Criteria: * TBI (ongoing, or in the prior 6 months) * Currently pregnant or breastfeeding * Progressive diseases - such as autoimmune epilepsies or diagnosis of a progressive neurological disorder * Status epilepticus within one year of study start * History of suicidal ideation or attempts in the last 6 months
focused ultrasound transducer.
Sham application of LIFU - energy blocked. Targeted to the same target as intervention.
Arctuva estimate
Actual pay is set by the research site.
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