Mayo Clinic
The purpose of this study is to compare Eosinophilic Esophagitis treatments Eohilia with Dupixent in their effects on diameter and scarring of the esophagus.
Eosinophilic esophagitis (EoE) is a chronic disease mediated by environmental allergens and type 2 immune inflammation which causes significant symptoms, food impactions, and stenosis. EoE is associated with significant esophageal stricturing disease. In particular, the odds of developing fibrostenotic disease in EoE more than double per decade of life, and the longer symptoms are present prior to diagnosis and treatment, the higher the likelihood of esophageal strictures being present. Dupilumab and budesonide oral suspension are key treatments for EoE. Dupilumab was FDA approved for EoE in…
Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male or female, aged ≥18 year of age at Mayo Clinic Rochester or Mayo Clinic Scottsdale at time of informed consent 4. Have a documented diagnosis of EoE per standard guidelines 5. Have histologically active EoE (defined as a peak eosinophil count \>15 eosinophils per high-power field; eos/hpf) 6. Weight ≥40 kg 7. Ability to take injectable or oral medication and be willing to adhere to the study intervention reg…
300 mg weekly injection
2mg twice daily
Arctuva estimate
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