Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study (NEPHRON)
The Cleveland Clinic
Summary
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
Description
The primary objective is to assess the efficacy of enalapril on hypertension as a second line agent compared to labetalol in the postpartum period. This is a pragmatic, unblinded, randomized trial of postnatal patients with hypertension who are on nifedipine postpartum and require a second oral agent. Patients will be evaluated for eligibility and consented when they require initiation of a single oral antihypertension agent, if they require IV antihypertensive therapy, or if they are on a single oral antihypertensive medication intrapartum. After consenting for the study, patients will be ini…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Postpartum women aged 18 years or older * Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features) * Taking Nifedipine 60 mg every 12 hours for blood pressure control * Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication * English speaking Exclusion Criteria: * Taking ≥2 antihypertensive agents during pregnancy * Heart block * Hea…
Interventions
- DrugNifedipine and Enalapril
Nifedipine 60mg by mouth every twelve hours plus Enalapril 5mg by mouth every twelve hours
- DrugNifedipine and Labetalol
Nifedipine 60mg by mouth every twelve hours plus Labetalol 200mg by mouth every twelve hours
Location
- Cleveland ClinicCleveland, Ohio