Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers
Marquette University
Summary
The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers. Data from a small group of participants will be analyzed after age-matched subjects undergo extraction and alveolar ridge preservation prior to implant placement. The data obtained in this pilot study will be used to plan a full-fledged study involving a larger number of smoking and non-smoking participants to compare the two groups.
Description
All research procedures will start after IRB approval. Patients of the Graduate Periodontics Clinic in need of extraction, bone graft and membrane will be recruited. There will be two groups (smokers and non-smokers) and their demographic and social, periodontal, surgery-related, anatomical and healing variables as well as patient-reported outcomes will be recorded at different time points (immediately before, during and immediately after surgery and 1, 2, 6 weeks and 4 months) in order to evaluate wound healing outcomes and differences between the groups. The demographic and social variables…
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Adult patients (18-75 years) * Good general health (controlled conditions) * Smokers (≥10 cigarettes/day for ≥5 years) and never smokers. Confirmation of smoking status will be done via use of a smokerlyzer. The cut-off point for distinguishing smokers from non-smokers is 8 carbon monoxide parts per million (ppm). * Periodontal status: periodontal health, gingivitis on intact or reduced periodontium, treated periodontitis * Intact post-extraction bony walls or less than 50% bone dehiscence * Distance at least 8 mm of vertical bone height between bone crest and anatomical…
Interventions
- Otherobservational study
Observational study; alveolar ridge preservation
Location
- Marquette University School of Dentistry Graduate Periodontics ClinicMilwaukee, Wisconsin