University of Chicago
Human intracranial electroencephalography (EEG) can provide brain-activity correlates of memory with high spatial and temporal resolution. This project will test functional relevance of these neural signals for memory behavioral performance using novel noninvasive and invasive stimulation methods. Findings will advance understanding of brain mechanisms for memory, as is needed to accelerate progress in the treatment of memory disorders.
Episodic memory impairment occurs when diseases impact the hippocampus and its network of interacting brain areas. Better understanding of brain mechanisms for memory is required to development treatments. This project will develop experimental approaches that use stimulation to manipulate brain-behavior relationships in humans and thereby directly test how the hippocampal network supports memory. Intracranial electroencephalography (iEEG) provides opportunities to study the neural basis of memory with high spatial and temporal resolution. Many experiments have identified iEEG signals associat…
Inclusion Criteria: * Age 18+ years old * Native English speakers * Normal or corrected-to-normal near and far vision
Study conditions will involve electrical stimulation delivered through non-invasive TMS. These different stimulation parameters will include the presence of stimulation (no stimulation versus stimulation) and the location of stimulation.
Study conditions will involve direct electrical stimulation delivered through implanted iEEG electrodes. These different stimulation parameters will include the presence of stimulation (no stimulation versus stimulation) and the location of stimulation across the same electrode or a different electrode.
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