Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage
Vanderbilt University Medical Center
Summary
The goal of this clinical trial is to test how storage temperature of deceased donor kidneys affects kidney function after transplant in adult patients receiving a kidney transplant. The main question it aims to answer is: • Do patients that receive a kidney transplant stored at 10 °C have improved post-transplant kidney function? Researchers will compare patients who receive kidneys stored at 10 °C versus kidneys stored at 4°C (on ice, i.e. conventional storage) to see if kidneys stored at 10 °C have improved function. Participants will: * Be made aware of and consent to receive a kidney transplant that had been stored at 10 °C * Have their urine collected 24 hours after surgery to be analyzed for research
Description
Kidney transplantation is a life-saving treatment for patients with end stage kidney disease, which affects nearly 800,000 patients in the United States. However, deceased donor kidney transplantation is often complicated by delayed graft function (DGF), conventionally defined as the recipient requiring hemodialysis within the first week after transplant. DGF is unfortunately common, occurring in 25% of all transplanted kidneys and portends worse long-term graft survival, higher rates of rejection, and increased recipient mortality. DGF commonly occurs because of ischemic reperfusion injury (I…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Participant inclusion criteria 1\. All adult single organ kidney transplant candidates on the waiting list at Vanderbilt University Medical Center (VUMC) will be eligible for enrollment. Participant exclusion criteria 1. Kidney transplant candidates less than 18 years old 2. Kidney transplant candidates that decline consent 3. Transplant candidates listed for multi-organ transplant Deceased donor organ inclusion criteria: 1. Donation after brain death or donation after circulatory death kidney donors, whose health care proxy has consented for donation and the possibility of research 2. De…
Interventions
- Device10˚C deceased donor kidney storage using Traferox XPort
Deceased donor kidneys will be stored using the Traferox XPort device to maintain an organ temperature of 10˚C during storage and transport until the time of transplant
Location
- Vanderbilt University Medical CenterNashville, Tennessee