Assessment of Functional Impact of Acute Respiratory Viral Infections in Older Adults - An International Multi-center Study
University Hospital, Grenoble
Summary
The prevention of infectious diseases in older adults remains a major public health challenge, as acute respiratory infections are a leading cause of hospitalisation, mortality, and functional decline worldwide. Immunosenescence and environmental exposures increase susceptibility to infection and reduce vaccine effectiveness in this population. Respiratory viruses, including influenza, SARS-CoV-2, respiratory syncytial virus, and human metapneumovirus, account for a substantial share of this burden, much of which is vaccine-preventable. However, their impact on functional decline and recovery in older adults remains insufficiently characterized. This international study aims to assess the effect of hospitalization for major respiratory viral infections on loss of autonomy in individuals aged 60 years and older, to inform targeted prevention and vaccination strategies.
Description
The prevention of infectious diseases in older adults represents a major public health challenge due to their substantial impact on morbidity, mortality, and loss of functional capacity. Acute respiratory infections are among the leading causes of hospitalization and death in this population worldwide. Ageing is associated with a progressive decline in immune function, resulting in increased susceptibility to infections and reduced vaccine effectiveness. In addition, environmental factors such as residence in collective living settings and repeated exposure to healthcare environments further…
Eligibility
- Age range
- 60+ years
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: * Male or female subjects aged 60 years or older * Hospitalized in a study center (emergency department, infectious disease, internal medicine or geriatric hospital wards…) for acute respiratory infection (refer to table 1 below for definition). * Confirmed positive PCR test for influenza, SARS-CoV-2, RSV, or human metapneumovirus (hMPV). Participants with co-infections with other viral or bacterial agents can be included. Exclusion Criteria: * Participants with conditions significantly impacting short-term functional status, such as severe disability (ADL score ≤2 or Cl…
Locations (24)
- University of Rochester School of Medicine, Infectious Diseases UnitRochester, New York
- University Hospital of AmiensAmiens
- Melun HospitalMelun
- Villeneuve Saint Georges HospitalParis
- University Hospital of PoitiersPoitiers
- University Hospital of ReimsReims