University of Chicago
Human intracranial electroencephalography (EEG) can provide brain-activity correlates of memory with high spatial and temporal resolution. This project will test functional relevance of these neural signals for memory behavioral performance using a novel noninvasive stimulation method. Findings will advance understanding of brain mechanisms for memory, as is needed to accelerate progress in the treatment of memory disorders.
This exploratory project merges noninvasive brain stimulation with invasive/neurosurgical electrophysiological recordings in humans to identify mechanisms for how stimulation targeting the hippocampal network affects episodic memory performance. Hippocampal network dysfunction is associated with episodic memory impairments in a variety of neurologic and psychiatric disorders. Core regions of this network such as the hippocampus are too deep within the brain to be directly affected by well-validated noninvasive neuromodulation approaches. Hippocampal Indirectly Targeted Stimulation ("HITS") add…
Inclusion Criteria: * Age 18+ years old * Native English speakers * Normal or corrected-to-normal near and far vision Exclusion Criteria: -iEEG electrode placement in area of parietal lobe that will interfere with placement of TMS coil for HITS stimulation
Study conditions will involve different parameters for electrical stimulation delivered using non-invasive TMS.
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