Massachusetts General Hospital
The Healey ALS MyMatch Common Screening Protocol (MCSP) is an observational study. The main goal of the study is to help connect adults living with ALS to Healey ALS MyMatch interventional clinical trials that may be a good fit for them. People who complete an MCSP Screening Visit will undergo: * clinical assessments * laboratory testing * biomarker analyses The above will be used to determine preliminary eligibility for enrolling ALS MyMatch trials. In addition to helping connect people to a Healey ALS MyMatch interventional clinical trial, the information will also be used to characterize clinical, genetic, and biofluid biomarker profiles. These profiles will help to match the right people to the right trials and evaluate the frequency of ALS-associated gene variants. Blood samples and DNA will also be stored for future ALS and biomarker research.
The MyMatch Common Screening Protocol (MCSP) is an observational study that is part of the Healey ALS MyMatch program. Healey ALS MyMatch is an early phase (Phase 1b or 2a), Amyotrophic Lateral Sclerosis (ALS) clinical trial program. ALS MyMatch is designed to help match adults living with ALS to Healey ALS MyMatch interventional clinical trials that may be a good fit for them. The first step in participating in Healey ALS MyMatch is to complete a screening visit for the MCSP. MCSP screening visit activities can be completed over a period of 45-days and some screening visit activities can be…
Inclusion Criteria: 1. Ability to provide written informed consent. 2. Adults \> 18 years of age. 3. Diagnosis of symptomatic ALS that meets either the revised El Escorial Criteria.(clinically possible, probable, probable lab-supported, or definite) or the Gold Coast Criteria. 4. Available or pending clinically obtained CLIA ALS genetic panel report. 5. Time since onset of weakness due to ALS ≤ 24 months at the time of MCSP screening. 6. Slow VC ≥ 65% of predicted capacity value for gender, height and age at screening. 7. Clinically unremarkable Complete Blood Counts as per SI's discretion, i…