Virginia Polytechnic Institute and State University
Testing repeated applications of low-intensity focused ultrasound (LIFU) on anxiety symptoms and outcomes.
This is a cross-over design with Real and Sham LIFU application with multiple weeks of follow-up. Follow-up includes anxiety metrics and mri scanning. LIFU application will be done using custom individual holograms to lens the waveform. Repeated applications of LIFU will be utilized. The NPU anxiety task will be utilized pre/post LIFU to assess outcomes. Questionnaires will be administered at each study visit.
Inclusion Criteria: * Patients with generalized anxiety disorder (GAD) symptoms; defined by a GAD-7 score \>= 10, OASIS score \>= 8, or a PSWQ score \>= 45. Exclusion Criteria: * Claustrophobia * Contraindications to MRI (certain implants or metal in the body) * Contraindications to CT (pregnancy) * Active medical disorder with CNS effects (e.g. Alzheimer's) * History of neurological disorder * History of head injury * Active alcohol or drug dependence
low-intensity focused ultrasound
Sham application of Low-intensity focused ultrasound
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