Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones
University of California, Los Angeles
Summary
Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications. Prescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and/or decrease the risk of future kidney stones. However, efficacy of alternatives to potassium potassium citrate are not well studied. This study seeks to evaluate sodium bicarbonate and assess its ability to alkalinize urine in a cohort of patients with kidney stones and compare this to prescription potassium citrate.
Description
Kidney stones affect 1 in every 11 people in the United States each year. A recurrence rate of 50% at 10 years highlights the importance of metabolic management, which has shown to be effective at decreasing the recurrence of stone disease. Specialty guidelines have recommended that clinicians offer pharmacologic therapy to recurrent stone formers. However, among kidney stone patients prescribed medication for stone management, only 30.2% are adherent to a medication regimen and even fewer, only 13.4%, are adherent with citrate medications. Prescription potassium citrate (Kcit) can be cost-pr…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adult \>18 years of age * History of nephrolithiasis * One 24h urine collections within one year of enrollment with hypocitraturia. * Patients currently utilizing or considering use of Kcit for stone prevention Exclusion Criteria: * Individuals with known metabolic disorders * Individuals with other known causes of nephrolithiasis * Anyone who, in the opinion of the PI, is unfit or unsuitable to participate in the study
Interventions
- DrugPotassium Citrate
20 mEq Kcit twice a day (40 mEq daily
- DrugSodium Bicarbonate
650 mg sodium bicarbonate twice a day (35.2 mEq daily)
Locations (6)
- University of California, Los AngelesLos Angeles, California
- University of California, DavisSacramento, California
- University of California, San DiegoSan Diego, California
- Brigham & Women'sBoston, Massachusetts
- CHUMMontreal
- Landspitali- National University Hospital of IcelandReykjavik