Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease
M.D. Anderson Cancer Center
Summary
To learn if gadopiclenol (a contrast agent) used during MRI scanning can help in the detection of early LMD.
Description
* Primary Objectives Primary Aim: Establish the ability of VUEWAY® (gadopiclenol) to detect early CNS LMD in brain MR while optimizing the ideal scan parameters including dose, sequences, and optimal timing for detection of CNS LMD in brain MRI. Brain MR offers a noninvasive alternative/complementary method to CNS sampling for detection of LMD. However, sensitivity for disease detection remains acceptable at best ranging from 33% in hematological malignancies in some studies to 75% (7, 8). This limits detection of early LMD thus potentially delaying diagnosis and initiation of life-saving trea…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients with tissue confirmed solid malignancy and standard of care brain MRI with equivocal results for LMD (questionable or possible) and negative LP CSF sampling or patients with high risk clinical LMD and negative brain MR and LP CSF sampling. Initially, we will target solid tumors, but if more patients are needed to meet the study power we will enroll liquid tumors. * Participants \> 18 years of age. * Participants are able to consent. Exclusion Criteria: * Participants with CSF sampling positive for LMD or MR brain/spine with definitive evidence of LMD. * Partic…
Interventions
- ProcedureMRI Scan
Given during standard of care
- DrugVUEWAY
Given by IV
- DrugGadavist
Given by IV
Location
- MD Anderson Cancer CenterHouston, Texas