Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion
Indiana University
Summary
The overall objectives of the proposed research are to: 1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced Laryngeal Obstruction (EILO) patients with the use of a novel miniature, soft wearable skin-mounted device, 2. Identify the mechanism/s of paradoxical respiratory control in EILO by quantifying the relationship between pulmonary mechanics, partial pressure of carbon dioxide (PCO2) maintenance, and vocal fold aperture prior to and during symptomatic and asymptomatic exercise ventilation, and 3. Identify unique biophysiological factors contributing to EILO among exercisers with and without EILO. Findings will be highly novel and clinically significant for early identification and management of EILO. For the study there are three separate visits: 1. Free running with the device on the neck 2. Exercise treadmill study 3. Undergoing MRI (Magnetic Resonance Imaging) of the vocal tract.
Eligibility
- Age range
- 18–26 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria for Exercise-Induced Laryngeal Obstruction (EILO): * Physically active \>2.5 hours per week * Patients with EILO, as diagnosed by routine clinical examination by physician and/or speech language pathologist * Age range of 18-26 years * Greater difficulty breathing inside compared to out and difficulty breathing which is exacerbated at peak exercise and stops 1-5 minutes after exercise * Score of 7 or higher on the Dyspnea Index, which is a validated instrument to capture participant self-report of upper airway dyspnea symptoms. * Classified as low risk, based on the modifie…
Interventions
- DrugCarbon Dioxide
Breathing Hypercapnic Gas (10% CO2 (carbon dioxide) and 21%O2 (oxygen), balance N210% (nitrogen))
- BehavioralBreathing treatment
Random Assignment to breathing conditions (rest breathing, rapid breathing, quick nasal sniff, pursed lip breathing), in a single blinded randomized design
Location
- Indiana UniversityBloomington, Indiana