University of Arizona
Neural diseases such as stroke can have distinct effects on the ability to navigate and orient compared to remembering daily events like when one last took medicine. This proposal seeks test rival hypotheses regarding the neural mechanisms underlying commonalities and differences in navigation and event-related memory, particularly as they relate to pre-existing knowledge. Such mechanistic insight could help inspire therapies that could be used to bolster intact brain function in a compensatory manner following strokes or other neural insults.
Contemporary models of spatial navigation and episodic memory (memory for events) postulate that their underlying computations emerge primarily from shared neural mechanisms within the medial temporal lobes. As part of the last two rounds of funding for this competitive renewal, the investigators began delineation of important cognitive and neural differences between navigation and episodic memory. The emerging new framework argues for navigation as a sensory-driven cognitive motor skill involving extracting spatial regularities and episodic memory as primarily internally driven and involving…
Inclusion Criteria: * Inclusion Criteria (for healthy young adults in fMRI studies) 1. Able to provide verbal and written informed consent 2. Fluent English speaker 3. At least 8th grade education 4. Age between 18-40 years. 5. Normal or corrected-to-normal eyesight Exclusion Criteria (for healthy young adults in fMRI studies) 1. Magnetic resonance imaging contraindications (e.g., metallic objects in body, claustrophobia) 2. Current use of anticonvulsant, neuroleptic, sedatives, or other medications known to affect cognition 3. Neurologic conditions affecting the brain (e.g., str…
effects of scopolamine on brain oscillations, navigation, and memory
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