Duke University
The purpose of this study is to complete performance testing of our custom optical coherence tomography (OCT) device to verify it can deliver retinal images of similar quality to a commercial OCT device. We will then add an angle-resolved low coherence interferometry (a/LCI module) to the device to make measurements of retinal tissue structure.
There is some evidence that certain changes in retinal structures could be an indicator of Alzheimer's disease (AD). We are developing a new technology that combines optical coherence tomography (OCT) and angle-resolved low coherence interferometry (a/LCI) to make light scattering measurements of retinal tissue structure. The first objective of this study is to compare performance characteristics of our custom OCT instrument to a commercial OCT instrument. Once we have optimized our device, the second objective will be to use the custom OCT-a/LCI device to identify retinal structure changes th…
All Participants: Inclusion Criteria: * able to provide informed consent Exclusion Criteria: * potentially confounding ocular conditions, such as: glaucoma, current corneal injury, retinal damage, diabetes, corrected distance visual acuity worse than 20/40 * eyes that have had intraocular surgery or retinal surgery, other than cataract surgery Participants with Alzheimer's Disease: Inclusion: \- mild cognitive impairment (MCI) or dementia due to Alzheimer's disease, confirmed by A/T/N classification Healthy Controls: Exclusion: \- has a memory or other neurodegenerative diagnosis (in…
retinal imaging with low-cost OCT-a/LCI device
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