Healthy Volunteers Enteral Nutrition Study
James Lewis
Summary
This research study is being conducted to determine the effects of enteral nutrition on healthy people. Enteral nutrition for the purpose of this study refers to the use of a specially developed formula taken by mouth that provides all essential nutrition either in the absence of food or to supplement the intake of foods. Enteral nutrition can be used for many reasons, such as to gain or lose weight, to treat food allergies, or to reduce inflammation in certain intestinal diseases. We would like to understand the effects of enteral nutrition in the absence of intestinal inflammation.
Description
Crohn's disease is an immune mediated condition that can affect any area of the gastrointestinal tract. The etiology is still unclear but is thought to be an aberrant response to the gut microbiota, inducing intestinal and systemic inflammation. Given the role of the immune system in the pathogenesis of Crohn's disease, the cornerstone of therapy has been targeted immunosuppression. However, despite the advances in pharmacologic treatments that have been seen in the past 20 years, a significant number of patients either do not respond to therapy or lose response after experiencing a benefit. I…
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Must be able to read and understand English 2. Must be able to sign a consent form for the study Exclusion Criteria: 1. BMI \<20 or \>30 2. Unintentional weight loss of \>10% in the last 3-6 months 3. Kidney disease 4. Diagnosis of cirrhosis 5. Taking diuretics 6. Anemia - Hemoglobin \<lower limit of normal in men or \<10 g/dL in women. 7. Taking iron supplements within 2 weeks for Visit 2.1 8. Taking prebiotic or probiotic supplements or any supplement including a multivitamin within 2 weeks of Visit 2.1 9. Taking antibiotics less than 4 weeks prior to Visit 2.1 10.…
Interventions
- Dietary SupplementKate Farms Peptide 1.5
Kate Farms Peptide 1.5
- OtherCrohn's disease exclusion diet
This study will use the components of the Crohn's disease exclusion diet Phase 1 which includes chicken breast, eggs, potatoes, bananas and apples
Location
- Penn Center for Advance Medicine, University of PennsylvaniaPhiladelphia, Pennsylvania