Effects of Psilocybin Microdosing on Cognition, Mood and Quality of Life: A Pilot Study
Yale University
Summary
This study is being conducted to evaluate how of 30 days of intermittently microdosed psilocybin affects mood, cognition, subjective well-being and structural/functional MRI results compared to a placebo. Investigators hypothesize that compared to placebo, 30 days of intermittently microdosed psilocybin will produce observable changes in mood, cognition, subjective well-being and MRI, in the absence of psychedelic experiences.
Description
This study is being conducted to evaluate the effects of 30 days of intermittently microdosed psilocybin in a parallel arm double-blind manner on mood, cognition, subjective well-being and structural/functional MRI compared to placebo, using validated psychological assessments and cognitive tests. Investigators hypothesize that compared to placebo, 30 days of intermittently microdosed psilocybin will produce observable changes in mood, cognition, subjective well-being and MRI, in the absence of psychedelic experiences. Demonstrating significant results in a population of healthy psychedelic n…
Eligibility
- Age range
- 21–40 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * No history of psychedelic use * Able to read, speak, and understand English * Able and willing to provide written informed consent, and willing to commit to study protocol * Women of childbearing potential must be on a highly effective birth control method Exclusion Criteria: * Positive screen for recreational drugs or alcohol on test day will result in rescheduling the appointment * Current mood, developmental, or psychotic disorders (e.g., schizophrenia, affective disorders) per DSM-V * Current or past alcohol or substance use disorder per DSM-V * IQ \<70 on the Wesc…
Interventions
- DrugPsliocybin
2.0mg powdered psilocybin derived from Psilocybe cubensis mushrooms, in capsules, provided three times weekly for four weeks
- DrugPlacebo
0mg matching capsules, provided three times weekly for four weeks
Location
- Olin Neuropsychiatry Research CenterHartford, Connecticut