Baylor Research Institute
To understand the impact of commonly used anesthetics on esophageal motility during FLIP topography.
Achalasia is a disease of unknown etiology in which inflammatory cells destroy ganglion cells in the wall of the esophagus.\[1,2 \] This inflammatory degeneration preferentially involves the inhibitory neurons in the esophageal myenteric plexus that are needed to effect normal peristalsis in the esophageal body and normal relaxation of the LES.\[3\] Thus, the classic manometric features of achalasia are: 1) absent esophageal peristalsis and 2) failure of the LES to relax with swallowing.\[4\] These physiologic abnormalities cause the typical achalasia symptom of dysphagia for both liquids and…
Inclusion Criteria: * Study subjects will include male and female patients age ≥18 to 75 years with dysphagia caused by achalasia (Type I, II or III) or by EGJ-outflow obstruction, suspected motility disorder, or undergoing an endoscopy to rule out an esophageal motility disorder who have been seen by Drs. Konda, Spechler, Nguyen, Reddy, Ellison, or Podgaetz. These patients will be undergoing an endoscopy and POEM procedure. Exclusion Criteria: * Age \<18 or \>75 years, patients unwilling or unable to provide informed consent; known gastrointestinal or thoracic or head and neck malignancy;…
FLIP imaging will occur twice per subject with the same baseline (propofol) assessment and then a second study assessment with propofol, sevofluorane, or isofluorane.
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