Advanced MRI for Visualization and Quantification of the Tumor Immune Microenvironment (TIME) in Glioblastoma
Jonsson Comprehensive Cancer Center
Summary
This phase III trial is evaluating whether a combination of three advanced magnetic resonance imaging (MRI) techniques, including chemical exchange saturation transfer (CEST) MRI, diffusion-relaxation correlation spectrum imaging (DR-CSI), and ferumoxytol-enhanced magnetic resonance imaging (Fe-MRI) are effective as non-invasive methods for assessing the cells and proteins that surround and interact with tumor cells (the tumor immune microenvironment) in patients with glioblastoma. Researchers understand that some types of brain tumors are harder to treat than others, but the reasons for this are not known in many cases. CEST MRI uses differences in the tissue microenvironment, like protein concentration or intracellular pH, to generate contrast differences. DR-CSI detects microstructural changes in tissue associated with immune cells infiltrating the tumor. Fe-MRI uses ferumoxytol as a contrast agent with MRI. Contrast agents are substances that are injected into the body and taken up by certain tissues, making the tissues easier to see in imaging scans. More advanced imaging techniques like CEST, DR-CSI, and Fe-MRI may offer less invasive methods than surgery or biopsy for helping researchers understand the tumor immune microenvironment in patients with glioblastoma, which may help researchers determine why some tumors are more resistant to treatment.
Description
PRIMARY OBJECTIVE: I. To establish the biological validation of advanced MRI as a non-invasive imaging modality for assessing the tumor immune microenvironment (TIME) in glioma. SECONDARY OBJECTIVES: I. Conduct more detailed correlation explorations focusing on relevant subpopulations, such as cluster of differentiation 4 (CD4+) versus ( cluster of differentiation 8 (CD8+) T cells and M1- versus M2-like tumor-associated macrophages (TAMs). II. Perform exploratory correlation analysis between tumor-averaged imaging measures with systemic immunological markers (T cell activation and interfer…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Male or female ≥ 18 years of age * Documentation of a confirmed or suspected diagnosis of glioblastoma * The participant is scheduled to undergo standard of care surgical tumor resection and/or biopsy * The participant has a measurable contrast-enhancing lesion (\> 1ml) based on the most recent MRI prior to resection/biopsy Exclusion Criteria: * Presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data * Individuals who cannot tolerate MRI scan, or with contraindication to 3-Tesl…
Interventions
- ProcedureBiospecimen Collection
Undergo collection of blood samples
- ProcedureChemical Exchange Saturation Transfer Magnetic Resonance Imaging
Undergo CEST MRI
- ProcedureDiffusion-Relaxation Correlation Spectrum Imaging
Undergo DR-CSI
- OtherElectronic Health Record Review
Ancillary studies
- DrugFerumoxytol
Given IV
- RadiationMagnetic Resonance Imaging
Undergo MRI
Location
- UCLA / Jonsson Comprehensive Cancer CenterLos Angeles, California