A Phase 1 Study in Healthy Subjects to Assess Pharmacokinetics Following Intravenous and Subcutaneous Administration of Risankizumab
AbbVie
Summary
The purpose of this study is to compare how the drug moves through the body following risankizumab subcutaneous (SC) and risankizumab intravenous (IV) doses.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Body weight between 40 kg and 100 kg inclusive at screening and upon initial confinement. * BMI is ≥ 18.0 to ≤ 32.0 kg/m2 after rounding to the tenths decimal at Screening. BMI is calculated as weight in kg divided by the square of height measured in meters. * A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile and a 12-lead ECG. Exclusion Criteria: * Exposure to any anti-interleukin-12/23 or anti interleukin-23 treatment for at least one year prior to Screening. * Intention to perform s…
Interventions
- DrugRisankizumab
Intravenous (IV)
- DrugRisankizumab
Subcutaneous (SC) Injections
Locations (2)
- CenExel ACT- Anaheim Clinical Trials /ID# 281821Anaheim, California
- Cpmi /Id# 281783Miami, Florida