Systemic Molecular Markers of Surgical Trauma in Periodontitis/Peri-implantitis Patients
Ohio State University
Summary
The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are: * How do the levels of inflammatory molecules in the blood change during a periodontal surgery? * How are the levels of inflammatory molecules in a person having surgery different from the levels in a person having a nonsurgical procedure? * Participants will be people who are having a periodontal surgery or a nonsurgical periodontal treatment as part of their dental care. Participants will be asked to let the investigator take blood samples from them before, during, and after the procedure is being done. The blood will later be analyzed for substances in the blood that are associated with inflammation.
Description
Periodontal disease is a chronic inflammatory disease and is associated with pro-inflammatory mediators such as increased levels of Tumor necrosis factor-alpha (TNF-a), Interleukin (IL)-17, IL-6, IL-1beta, and C-reactive protein (CRP) within gingival tissues as well as gingival crevicular fluid. IL-17 is a pro-inflammatory cytokine that promotes recruitment of neutrophil and stimulates host cells to produce other pro-inflammatory factors such as IL-1, IL-6, TNF-, and CRP that are related to the acute phase of vascular inflammation. There is evidence supporting increased levels of these mediato…
Eligibility
- Age range
- 21–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults 21-75 years of age * Systemically healthy * Non-smoker * scheduled to receive nonsurgical or surgical periodontal treatment under IV sedation Exclusion Criteria: * Patients who have localized form of the disease (less than 30% of available tooth/implant sites are affected with the disease) * Non-english speaking individuals since informed consent form will be in English only. * Patients with uncontrolled systemic diseases (such as metabolic diseases, obesity, diabetes, high blood pressure) since these types of chronic inflammatory challenges would cause increase…
Interventions
- OtherBlood samples for inflammatory markers
Blood samples will be obtained before the start of the procedure, the midpoint of the procedure, and the end of the procedure.
- Procedureperiodontal surgery
Periodontal/peri-implant surgical interventions, with or without IV sedation, as based on treatment needs
- ProcedurePeriodontal maintenance
Regular cleaning to maintain health after surgical treatment for periodontal disease
- ProcedureNon-surgical deep cleaning
Debridement under local anesthesia, as based on treatment needs
Location
- The Ohio State University Graduate Periodontics ClinicColumbus, Ohio