Radiofrequency Ablation For Recurrent Parathyroid Carcinoma
M.D. Anderson Cancer Center
Summary
The study will be an effectiveness study. The study will include enrollment of a total of 20 patients with at least one PC lesion for ultrasound guided RFA to PC recurrence in the neck to assess the effectiveness in reducing patient's hypercalcemia. Patients will have surgically proven PC from prior parathyroidectomy and suspicious PC visible on ultrasound and request for treatment for uncontrolled hypercalcemia (Figure 1).
Description
Primary Objective: • Evaluate treatment response of RFA of recurrent PC by means of longitudinal monitoring patient serum calcium level and PTH. Secondary Objectives: * Evaluate the sonographic features of the recurrent PC induced by RFA. * Evaluation of procedure-related complications * Disease free survival until recurrence of hypercalcemia
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Adult patients with recurrent parathyroid carcinoma that was previously resected and persistent or recurrent hypercalciemia. Patients are not surgical candidates or strongly desire nonsurgical intervention. Eligibility for enrollment will be based upon meeting inclusion and exclusion criteria as detailed in section 4.1 and 4.2. The study will include 20 eligible patients or lesions. Utmost care will be taken to minimize risk to patients through careful selection of patients and scheduled assessments (Table 1). Patients will be recruited through the Endocrine, Endocrine su…
Interventions
- DeviceUltrasound-guided RFA
Participants will be positioned supine with full neck extension. Preprocedural intraoperative PTH will be drawn. Radiofrequency ablation (RFA) will be performed on one or up to 5 nodules on ipsilateral side per participant.
Location
- UT MD AndersonHouston, Texas