A Pilot Trial of Bridging Radiation Therapy With Oral Vancomycin for Patients With B-cell Lymphomas Undergoing CAR-T Therapy
Abramson Cancer Center at Penn Medicine
Summary
This clinical trial assesses whether it is feasible to use radiation therapy with vancomycin prior to CAR T-cell therapy for patients with large B-cell lymphomas
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Male or female subject aged ≥ 18 years. * Pathologically confirmed B-cell lymphoma patients intended for standard of care CAR-T * ECOG Performance Status ≤ 2. * Subjects must be clinically eligible to receive standard of care anti-CD19 CAR-T * Subjects must have at least one site of disease amenable to radiation, with the ability to deliver radiation to at least 50% of involved sites * Subjects must have at least one site of measurable disease based on CT or FDG PET * Subjects must not be anticipated to require additional therapy beyond bridging radiation listed in this…
Interventions
- DrugVancomycin 125mg
oral
Location
- Abramson Cancer Center, University of PennsylvaniaPhiladelphia, Pennsylvania