Role of Nitric Oxide (NO) in Endothelial Dysfunction in Premenopausal Women With Posttraumatic Stress Disorder (PTSD)
University of Minnesota
Summary
This research study is conducted to better understand why women with post-traumatic stress disorder (PTSD) have higher risk of cardiovascular disease as they get older. This study looks at how trauma and PTSD affect blood vessels in young women by testing whether the dietary supplement beetroot juice might help improve the function of blood vessels in women suffering from PTSD.
Eligibility
- Age range
- 18–40 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Women ages 18-40 (female as defined biologically) * Premenopausal as indicated by self-report of menstrual cycles. * Trauma-exposed with or without PTSD. Diagnostic Criteria for both trauma exposure and PTSD will be obtained via clinical interview, medical records, and self-report. * Stated willingness to comply with all study procedures and availability for the duration of the study * Diagnosis of major depression (MD). * Comorbid Psychiatric Conditions: Participants with other anxiety disorders, and bipolar disorder without psychotic features, mild to moderate traumati…
Interventions
- Dietary SupplementBeetroot Juice
We will use James White Beet It sports shot (70ml), which contains 400 mg of dietary nitrate
- Dietary SupplementPlacebo Juice
James White Nitrate Depleted Placebo ( 70 ml) will be used as a placebo
Location
- University of MinnesotaMinneapolis, Minnesota