A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement
AdventHealth
Summary
The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.
Eligibility
- Age range
- 21–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Provision of signed and dated informed consent from 2. Stated willingness to comply with all study procedures and availability to attend all required visits for the duration of the study. 3. Age 21- 75 4. Unilateral total knee arthroplasty at Colorado Joint Replacement 5. All individuals will be screened for drug use (opioid use, illicit drug use) at their preoperative appointment 6. For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation. Exclusio…
Interventions
- DrugMethadone
Subjects randomized to receive methadone will be given one dose of methadone 0.15mg/kg intravenously dosed based on ideal body weight administered by the anesthesia team prior to surgical incision
Location
- AdventHealth PorterDenver, Colorado