Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two Different Systems
University of California, San Francisco
Summary
The investigators would like to study the differences in the quality of Platelet Rich Plasma (PRP) between two different machines in those with knee osteoarthritis. Knee osteoarthritis means your cartilage has been worn down, and it affects your knee joint. Both machines, the APEX Biologix XCELL PRP System and the Emcyte PurePRP Supraphysiologic Concentrating System, are FDA approved, commercially available, and makes PRP. The investigators will check if the platelets in the PRP have different amounts or work differently. The investigators will also assess participants symptoms after the injection and compare the two different preparation systems.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Kellgren-Lawrence (KL) Grade 1-3 knee osteoarthritis * Symptoms of knee osteoarthritis for at least 3 months before presentation in one knee * Will be able to attend and perform physical therapy Exclusion Criteria: * Received injection therapy for knee osteoarthritis in the past 6 months * Have severe arthritis diagnosed in ≥1 major joint by radiology criteria * History of septic arthritis * Underwent knee surgery for osteoarthritis or osteochondral defects within 1 year before randomization (e.g., autograft or allograft surgery) * Have had high tibial osteotomy, parti…
Interventions
- BiologicalPlatelet Rich Plasma
The Platelet Rich Plasma (PRP) participants will receive in this study will be made by Emcyte PurePRP Supraphysiologic Concentrating System or the APEX Biologix XCELL PRP System.
- DeviceEmcyte PurePRP Supraphysiologic Concentrating System
Platelet Rich Plasma (PRP) will be made by the Emcyte PurePRP Supraphysiologic Concentrating System.
- DeviceAPEX Biologix XCELL PRP System
Platelet Rich Plasma (PRP) will be made by APEX Biologix XCELL PRP System.
Location
- University of California San FranciscoSan Francisco, California