Comparing Placebo Versus Antibiotics for Acute Uncomplicated Diverticulitis

Summary

The goal of this clinical trial is to determine whether antibiotics improve recovery from acute uncomplicated diverticulitis (AUD) in racially and ethnically diverse United States clinical practice. The main questions it seeks to answer are: * What is the feasibility for completing a subsequent definitive efficacy trial of antibiotics vs. placebo to treat AUD? * What are the needs for successful recruitment of racial and ethnic subgroups? * What are the effects of a placebo compared to antibiotics for AUD on a range of key patient-centric efficacy and safety endpoints? * How do such effects differ by race and ethnicity? Researchers will compare a placebo to antibiotics to see if AUD can be treated without using antibiotics. Participants will: * Take two antibiotics or a matching placebo every day for 10 days * Receive analgesia, gastric protection, diet modifications, and a follow-up * Submit daily photos of pills to the study team to verify adherence

Eligibility

Age range

18–90 years

Sex

All

Healthy volunteers

No

Interventions

• Drug
  Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet

  amoxicillin-clavulanate:1 tablet \[875 mg amoxicillin; 125 mg clavulanic acid\] every 8 hours

• Drug
  Placebo

  A placebo matching the antibiotic arm's treatment regimen will be administered for 10 days

• Drug
  Metronidazole

  metronidazole: 500 mg every 12 hours

• Drug
  Cefuroxime

  cefuroxime: 500 mg every 12 hours

Location