Dose Dependent Response to Interlaminar Steroid Injections for Lumbar Radiculopathy
University of Miami
Summary
This study aims to evaluate the efficacy of interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, to evaluate the efficacy of interlaminar steroid injections at improving quality of life and function in lumbar radiculopathy at varying doses, and to evaluate difference in efficacy between triamcinolone and dexamethasone interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, with the overarching hypotheses that there is no difference in reported pain reduction, quality of life, or function among patients receiving low, moderate, or high doses, and no difference in reported pain reduction between triamcinolone and dexamethasone.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults able to consent * Lumbar radiculopathy with MRI-confirmed pathology * No history of back surgery * Use of interlaminar approach lumbar spine injections * No use of oral pain medication other than Tylenol or Acetaminophen during the 6 weeks after injection Exclusion Criteria: * Adults unable to consent * Individuals who are not yet adults (infants, children, teenagers) * Pregnant women * History of back surgery * Use of oral pain meds other than Tylenol or Acetaminophen during the 6 weeks after injection
Interventions
- DrugTriamcinolone 10 Mg/mL Injectable Suspension
A single 10 mg Triamcinolone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
- DrugTriamcinolone 40 Mg/mL Injectable Suspension
A single 40 mg Triamcinolone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
- DrugTriamcinolone 80 Mg/mL Injectable Suspension
A single 80 mg Triamcinolone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
- DrugDexamethasone 2 MG
A single 2 mg Dexamethasone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
- DrugDexamethasone 4mg
A single 4 mg Dexamethasone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
- DrugDexamethasone 8 MG
Location
- University of MiamiMiami, Florida