University of Pennsylvania
The current study presents a unique opportunity to measure the direct effects of transcranial magnetic stimulation (TMS) by using intracranial electrodes to record neural activity in deep brain regions when TMS single pulses are delivered. If TMS can evoke downstream responses in neural networks of the human brain, it can be a feasible way to study circuit engagement and connectivity.
Inclusion Criteria: 1. Patients who received (or are scheduled to receive) intracranial electrode implantation surgery as part of standard clinical care or as participation in an ongoing research study for the treatment of neurological and/or psychiatric conditions at Pennsylvania Hospital 2. Adult patients, 21 to 75 years of age 3. Patients considered to be in a stable medical condition, in the opinion of the PI 4. Patients who are able to demonstrate comprehension of instructions in the English language, in the opinion of the PI 5. Patients who are able to provide informed consent and fully…
single pulse TMS will be administered when participants have intracranial electrodes implanted to measure neuronal activity.
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