Biomarker Responsiveness of Nanopulse Laser Therapy in Treatment of Traumatic Brain Injury
The University of Texas Medical Branch, Galveston
Summary
The purpose of this study is to evaluate the safety and effectiveness of a novel noninvasive therapy, Nanopulse Laser Therapy (NPLT), to improve recovery following traumatic brain injury (TBI).
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults aged 18 years or older at the time of enrollment * Confirmed diagnosis of moderate to severe TBI (clinical assessment and radiographic evidence) * Admission to the neurosurgical or neurocritical care service with anticipated need for intracranial monitoring (e.g., microdialysis, ICP probe) * Able to initiate treatment within 48 hours of admission * Informed consent obtained from patient or legally authorized representative Exclusion Criteria: * Patients younger than 18 years of age * Known or suspected pregnancy (verified via urine pregnancy test for females of…
Interventions
- DeviceNano-Pulsed Laser Therapy (NPLT)
Nano-pulsed laser therapy (NPLT) is a novel, noninvasive therapeutic modality that combines near-infrared (NIR) laser light with optoacoustic stimulation. The therapy is delivered using an Optical Parametric Oscillator (OPO) laser system capable of emitting tunable wavelengths within the near-infrared spectrum (690-950 nm). The laser delivers nanosecond-duration pulses (10 nanoseconds) at a repetition rate of 20 Hz, with a maximum pulse energy of up to 150 millijoules per pulse. Energy delivery is precisely calibrated to 0.05 J/cm² per pulse to ensure controlled and consistent exposure. The pulsed NIR energy generates localized optoacoustic effects intended to produce acute physiological responses without tissue ablation or thermal injury. NPLT is administered noninvasively during the acute post-injury period following moderate to severe traumatic brain injury, in accordance with the study protocol.
Location
- University of Texas Medical BranchGalveston, Texas