Duke University
This pilot feasibility study aims to evaluate transcranial magnetic stimulation (TMS) targeting the prefrontal cortex in patients with fibromyalgia syndrome (FMS). The study will assess preliminary efficacy and mechanisms of central nervous system changes using neuroimaging, behavioral tasks, sensory testing, and neuroimmune markers. Participants will undergo MRI scans, multi-day TMS sessions, and complete questionnaires. The goal is to generate pilot data for future trials on neuromodulation for chronic pain.
This is a study to compare activity in the brains of female adults with chronic pain before and after a new intervention. What the researchers learn by doing this study may help them understand how the brain works and how to develop new and targeted treatments for adults with chronic pain. Female participants in this study will come to Duke Hospital for up to 6 visits. First, there is an MRI scan visit. Then, there are 4 intervention (TMS) visits, one after the other over 4 days. Next, there is an identical follow up MRI scan visit. Afterwards, there is a one month, three month, and six month…
Inclusions: 1. Female and ages 18 + 2. Ability to read/understand English and give consent to participate 3. Physician diagnosis \& confirmation of primary fibromyalgia syndrome 4. Verbal agreement to maintain dose of prescribed medication (if any) constant throughout the study, except exclusion medication and except if there is a medical emergency requiring changes in medication 5. If enrolled in psychotherapy, verbal agreement to maintain (not change or stop) the psychotherapy during the study 6. Absence of use of opioid medications (during the previous 90 days, and no greater than a 30-day…
TMS protocol delivered via MagPro X100 stimulator with figure-8 coil targeting prefrontal cortex.
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