GLOW Study: A Randomized Trial to Evaluate the Effects of Triple Support Protein on Glucose, Lifestyle, and Overall Well-being in Women
University of North Carolina, Chapel Hill
Summary
This single-site, randomized, blinded, placebo-controlled study will evaluate whether 4 weeks of daily Triple Support Protein powder improves glycemic control and overall well-being in healthy women aged 30-60 years. Participants will undergo baseline testing (DXA, fasting blood, standardized meal test with 2-hour glucose and insulin sampling), complete one acute supervised dose, and then consume a daily supplement for 4 weeks. During the final 14 days, participants will wear a continuous glucose monitor. Outcomes include postprandial glucose AUC, insulin sensitivity, and body composition.
Description
Midlife women experience hormonal changes that can impair metabolic health, sleep, and cognition. Triple plant-based protein powder includes creatine and fiber aimed at glycemic control, muscle support, and satiety. Design: 40 participants randomized (1:1) to Triple Protein Support vs. matched placebo for 4 weeks, with acute and chronic phases, weekly check-ins. Assessments: Baseline and end-of-study DXA and bloods; standardized meal tests with 2-hour glucose/insulin sampling; Analysis: Mixed-model ANOVA for primary and secondary endpoints with α=0.05.
Eligibility
- Age range
- 30–60 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Females aged 30-60 years. * BMI 18.5-40 kg/m\^2. * Recreationally active (≥30 min/wk moderate intensity exercise). * Healthy and free from disease per health history questionnaire. * Willing to abstain from caffeine, tobacco, and alcohol for 24 hours before testing days. Exclusion Criteria: * Currently supplementing whey protein. * Pregnant or nursing. * Lactose intolerant. * Currently using creatine monohydrate. * Severe hearing or speech impairment or inability to speak English
Interventions
- Dietary SupplementTriple protein support
Plant based protein + creatine + fiber
- Dietary SupplementPlacebo
Non-caloric matched placebo
Location
- Department of Exercise and Sport Science, Applied Physiology LaboratoryChapel Hill, North Carolina