Integrative Skin Science and Research
This study is being done to help better understand how the gut and skin bacteria of the body change when people with acne are treated with Sarecycline or Doxycycline. The bacteria in the gut and on the skin will be studied to see how each treatment may affect them and whether they change the profile of the bacteria that is present.
Inclusion Criteria: 1\) Diagnosis of acne vulgaris with: * At least 10 inflammatory lesions (papules, pustules, and nodules) up to 100 noninflammatory lesions (open and closed comedones) * No more than 2 nodules on the face Exclusion Criteria: 1. Dermatological condition of face or facial hair that could interfere with clinical evaluations 2. Subjects who have used the following medications (topical refers only to the facial area) will not be eligible: 2a) Within 2 week prior to randomization: * Topical acne medications such as retinoids, antibiotics, hormonal modulators * Topical benzoy…
One tablet by mouth (weight based dosing at 1.5 mg/kg and rounded to the closest tablet dose at either 60 mg, 100mg, or 150 mg tablet) once a day with food and a full glass of water (about 8 ounces)
100 mg twice daily with food and a full glass of water (about 8 ounces)
Arctuva estimate
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