Effects of Respiratory Muscle Training and Aerobic Exercise on Lung Health in Smokers: A Pilot Parallel-Group Study for Lung Cancer Prevention
Roswell Park Cancer Institute
Summary
This clinical trial studies whether home-based respiratory muscle training (RMT) and aerobic exercise (AE) programs can be used to improve lung health in current and former cigarette smokers. Lung cancer, the leading cause of cancer death, is overwhelmingly caused by exposure to cigarette smoke. Research suggests that daily activity reduces lung cancer risk in current and former smokers. However, current and former smokers are generally not active and new approaches to improve lung health are needed. During the home-based RMT program, participants use a handheld device to complete breathing exercise sessions consisting of breathing in and out against adjustable resistance. During the home-based AE program, participants complete aerobic exercises using a stationary bike working at a moderate workload against adjustable resistance. The home-based RMT and AE programs may be effective ways to strengthen the breathing muscles, which may improve lung health in current and former cigarette smokers.
Description
PRIMARY OBJECTIVES: I. Evaluate the feasibility of delivering a home-based AE and RMT program in individuals at high risk for lung cancer. II. Assess the effects of AE and RMT on patient-reported outcomes (PROs), including QoL, fatigue, dyspnea, performance metrics such as respiratory muscle strength and lower extremity strength; the 6-minute walk test; and daily activity levels in high-risk individuals. III. Investigate whether RMT and/or AE improve peripheral and exhaled biomarkers associated with lung injury, inflammation, and/or oxidative stress. OUTLINE: Participants scheduled for a c…
Eligibility
- Age range
- 50+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age ≥ 50 years old * Current smoker with a ≥ 20-pack-years history * Former smoker within the past 15 years, with a history of ≥ 20 pack-years (CT scan cohort only) * Participant must be able to speak, read and comprehend English language * Cognitively capable of following direction and performing the intervention * Understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure Exclusion Criteria: * Any previous lung cancer diag…
Interventions
- ProcedureAccelerometry
Ancillary studies
- OtherAerobic Exercise
Complete tailored intensity AE cycling sessions
- ProcedureBiospecimen Collection
Undergo blood, nasal swab, exhaled breath, and urine sample collection
- OtherEducational Intervention
Receive AE and RMT education
- OtherElectronic Health Record Review
Ancillary studies
- OtherPhysical Performance Testing
Ancillary studies
- ProcedureRespiratory Muscle Training
Location
- Roswell Park Cancer InstituteBuffalo, New York