Effects of Avocado Consumption on Inflammation and Insulin Sensitivity in Adults With Elevated High Sensitivity-C-reactive Protein (Hs-CRP): A Randomized, Controlled Crossover Trial
Midwest Center for Metabolic and Cardiovascular Research
Summary
The objective of this trial is to assess the effects of replacing foods high in refined carbohydrates, particularly added sugars, with avocado (isocaloric substitution) on biomarkers of inflammation and insulin sensitivity in adults with elevated hs-CRP and central adiposity. Eligible participants will complete two 4-week interventions (1 avocado/d and control) separated by a 2-week washout phase. Participants will complete a total of 7 clinic visits including one screening visit (visit 1, -7 days), one baseline visit (visit 2, day 0), two visits during each 4-week diet condition (visit 3 \& 6 on day 21 and visits 4 \& 7 on day 28), and one visit at the conclusion of the washout phase/start of the second condition (visit 5, day 0).
Eligibility
- Age range
- 21–74 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Male or female 21 - 74 years of age, inclusive; 2. Baseline hs-CRP ≥2 to \<10 mg/L; 3. Central adiposity (waist circumference ≥35 inches in women and ≥40 inches in men); 4. Body mass index 25.0 to 39.9 kg/m2; 5. Normally active and judged by the Investigator to be in generally good health, based on medical history and screening measurements; 6. Willing to consume daily study foods during each diet condition; 7. Willing to maintain his/her regular physical activity pattern throughout the study period; 8. Willing to follow test day instructions (refrain from consumption o…