Cord Blood Transplantation in Children and Young Adults With Hematologic Malignancies

Summary

The purpose of this study is to find out whether Cord Blood Transplantation/CBT as the first or second transplant is an effective treatment for children and young adults with blood cancer.

Eligibility

Age range

Up to 26 years

Sex

All

Healthy volunteers

No

Interventions

• Biological
  Cord Blood Units

  Cord Blood \[(HPC(CB)\] products are minimally manipulated unrelated allogeneic cord blood units that have been collected, processed and stored in public Cord Blood banks

• Radiation
  Total Body Irradiation

  Hyper-fractionated TBI is administered by a linear accelerator at a dose rate of \<20 cGy/minute. Treatment planning begins with simulation.

• Drug
  Cyclophosphamide

  Cyclophosphamide is an alkylating agent that prevents cell division by cross-linking DNA strands and decreasing DNA synthesis.

• Drug
  Fludarabine

  Fludarabine phosphate is rapidly dephosphorylated to 2- fluoro-ara- A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2- fluoro-ara-ATP

• Drug
  Clofarabine

  Clofarabine, a purine (deoxyadenosine) nucleoside analog, is metabolized to clofarabine 5'-triphosphate.

• Drug
  Busulfan

Locations (7)