Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome
University of Rochester
Summary
This observational research study is designed to learn more about how the brain processes sound in individuals with Rett syndrome. Participants will complete a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. In addition, parents or caregivers will complete questionnaires and an interview about the participant's symptoms, communication abilities, daily functioning and overall health. The information collected from this study may help researchers better understand brain activity patterns and clinical features associated with Rett syndrome and support future research efforts.
Description
This study is an observational research project conducted under a broader IRB approved protocol that includes multiple neurodevelopmental and neurodegenerative conditions. The current ClinicalTrials.gov record describes only the Rett syndrome component of the research and reflects the procedures currently being performed for participants with Rett syndrome and age/sex-matched controls. All participants in this study will undergo a noninvasive electroencephalogram (EEG) recording to measure brain responses to auditory stimuli. During the EEG, participants will listen to simple sounds through h…
Eligibility
- Age range
- 2+ years
- Sex
- All
- Healthy volunteers
- Yes
Rett Syndrome Participants: Inclusion Criteria: * Have a clinical diagnosis of classic Rett syndrome * Have a pathogenic MECP2 genetic variant confirmed via genetic testing * Are past the clinical regression stage * Are within the eligible age range for the study (2 years or older) * Are able to tolerate the noninvasive EEG recording * Parent or caregiver is willing and able to provide parental permission and complete questionnaires and interviews Exclusion Criteria: * Experiences hearing impairment or hearing loss * Presence of medical conditions that would prevent safe participation in E…
Interventions
- ProcedureElectroencephalogram (EEG) Recording
Participants will undergo a noninvasive electroencephalogram (EEG) recording to measure brain activity in response to auditory stimuli. During the procedure, participants will listen to simple sounds through headphones while brain signals are recorded. No behavioral responses are required.
Location
- Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical CenterRochester, New York