Beatriz Luna
The study will use a PET-based measure of brain cell (neuron) connections (synapses) in young adults who have also obtained an MRI, to assess how the loss of brain cell connections (synaptic pruning) is captured by MRI-based measures. This will inform youth MRI studies to understand neurotypical brain development that can help identify abnormal trajectories as in mental illness.
The loss of brain cell (neuron) connections (synapses) through human development, known as synaptic pruning, has been characterized in postmortem studies but how this proceeds in live humans as they age into adulthood is not well understood. This study will use the PET tracer \[11C\]UCB-J which provides a direct measure of synaptic density, in conjunction with previously acquired ultra-high field MRI, in a group of young adults in order to understand how standard MRI-based measures reflect changes in the density of synapses. PET \[11C\]UCB-J is known to measure the density of synaptic connecti…
Inclusion Criteria: * Males or females between 18-26 years of age, AND currently enrolled in the Parent Project (R01MH067924) Exclusion Criteria: (these exclusion criteria are outlined in the Parent Project) * Head injury with loss of consciousness over an hour. * A vision problem or eye movement problem (such as lazy eye, double vision, blurred vision, or color blindness). * A learning disability and/or ever had an Individualized Education Plan (IEP) in school. * Significant neurological or metabolic illness: Epilepsy, Meningitis, Encephalitis, Diabetes, Huntington's disease. * Diagnosed w…
\[11C\]UCB-J (\~ 15 mCi and ≤ 6μg) will be injected as a slow intravenous bolus. Following an intravenous bolus injection of \[11C\]UCB-J, the participants will be positioned in the scanner for a low dose CT scan (for attenuation correction) fifty-five minutes after the \[11C\]UCB-J injection, and emission data will be collected.
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