Effects Of Nocturnal Dronabinol Use On Obstructive Sleep Apnea Treatment And Physiological Outcomes
Mayo Clinic
Summary
The purpose of this study is to determine if oral dronabinol prior to sleep can improve CPAP adherence and sleep quality in humans. We also seek to determine if combination therapy of CPAP and pre-sleep dronabinol is associated with improved BP regulation. We will also explore BP regulatory mechanisms and whether these are impacted differently between traditional CPAP therapy and combination CPAP/dronabinol.
Eligibility
- Age range
- 21–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria * 21 - 70 years of age * Biological male or female * AHI between 15 - 50 events/hour Exclusion Criteria * BMI \> 35 kg/m2 * Diagnosed psychiatric disorders * Hypotension * History of seizures * History of substance abuse or recreational drug use or positive urine drug screen * History of uncontrolled disease including: * Cardiovascular * Pulmonary * Gastrointestinal * Pancreatic * Hepatic * Renal * Hematological * Endocrine (including Type I Diabetes) * Neurological * Urological * Pregnant or breastfeeding * Use of certain antimicrobial, chemotherapeu…
Interventions
- DrugDronabinol
10 mg dose of Dronabinol daily for 6 weeks
- DrugPlacebo
10 mg dose of Placebo daily for 6 weeks
Location
- Mayo Clinic in RochesterRochester, Minnesota