Growth Hormone Resistance of Beta-cells in People With Impaired Fasting Glucose vs Impaired Glucose Tolerance
University of Missouri-Columbia
Summary
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with impaired fasting glucose or impaired glucose tolerance at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing type 2 diabetes.
Eligibility
- Age range
- 18–59 years
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: * body mass index \>18.5kg/m2 and \<45.9kg/m2 * impaired fasting glucose \>/= 100mg/dL, \</= 126mg/dL or impaired glucose tolerance on 75g oral glucose tolerance test (blood glucose 140 to 199mg/dL at two-hours) Exclusion Criteria: * pregnant, planning to become pregnant during the study, or breastfeeding * current diagnosis or history of type 1 or type 2 diabetes * use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists) * history of bariatric surgery * known, uncontrolled hypothyroidism * history of intracranial hypertension, including papi…
Location
- University of Missouri School of MedicineColumbia, Missouri