The Effects of Timolol On Healing and Cosmesis of Mohs Scalp Wounds: An Open Label Trial
Geisinger Clinic
Summary
The goal of this study clinical trial is to learn if topical timolol can accelerate healing and improve the cosmetic appearance of surgical wounds on the scalp following Mohs surgery. It will include Geisinger patients 18 year or older who undergo Mohs surgery of the scalp with planned wound healing by secondary intent. The main questions in aim to answer are: 1. Compare wound healing speed between patients treated with topical timolol and those receiving standard wound care only. 2. Compare cosmetic outcomes using topical timolol and standard wound care. 3. Evaluate the impact of topical timolol on the number of unplanned follow-up visits and calls related to delayed wound healing. Participants will be asked use either topical timolol or use standard wound care to treat their Mohs surgery scalp wound. They will follow-up around 4, 8 and 12 weeks.
Description
Mohs surgical wounds of the scalp and anterior lower leg share several characteristics. They both involve convex surfaces with high tissue tension, and both are often allowed to heal by secondary intent. Secondary intent healing on the scalp is a slow process, with studies noting a mean time for re-epithelialization ranging from 7 to 26 weeks, depending on if the periosteum is intact. Recently, topical timolol has garnered attention for its effectiveness in promoting healing of open wounds on the lower extremity. Studies have shown improved healing in patients with comorbidities, an impressiv…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Age: Adults aged 18 years and older. Condition: Patients who have undergone Mohs surgery on the scalp. Consent: Ability to provide informed consent. Willingness to Participate: Willingness to comply with study procedures and attend follow-up visits. Healing by Secondary Intention: Wounds intended to heal by secondary intention. Exclusion Criteria: * Known allergy or sensitivity to timolol or any components of the study medication. * Bronchial asthma or history of bronchial asthma * Severe chronic obstructive pulmonary disease (COPD) * Sinus bradycardia * Second or third…
Interventions
- DrugTopical Timolol
Topical timolol is the active drug that will be compared to placebo in the trial.
- DrugNormal Saline
Normal saline is the placebo that will be compared to topical timolol in the trial.
Location
- Geisinger Dermatology WoodbineDanville, Pennsylvania