LiveWellLung: A Prehabilitation Intervention Program to Promote Resiliency and Operative Success Among Adults Receiving Lung Cancer Surgery (ROAR-LCS) With Biospecimen Collection
Ohio State University Comprehensive Cancer Center
Summary
This clinical trial tests two different physical therapy and relaxation interventions, one in-person and at-home called Resiliency and Operative Success for Adults Receiving Lung Cancer Surgery (ROAR-LCS) and one virtually called BeFitMe. These programs that take place before and after standard of care lung cancer surgery, called prehabilitation programs, promote resiliency and patient outcomes (operative success) for adults receiving lung cancer surgery. Lung cancers occur in the chest and often cause symptoms for patients. Poor physical performance and negative mood are two risk factors for a decline in functional status after surgery. Physical therapy and relaxation interventions (i.e. progressive muscle relaxation) are two such interventions that may improve physical and emotional recovery including a potential shortened hospital stay for patients receiving surgery for lung cancer. Starting these intervention programs early alongside cancer treatment can improve symptoms, improve functional status and quality of life, help with emotional needs of patients, improve recovery time, and may even prolong life. ROAR-LCS and BeFitMe may promote resiliency and operative success for adults receiving lung cancer surgery.
Description
PRIMARY OBJECTIVE: I. To evaluate feasibility of the two peri-operative programs, as defined by participant adherence and retention rates within their respective interventions. EXPLORATORY OBJECTIVE: I. Associating gut microbiome diversity and T cell senescence profiles (peripheral blood) at baseline and end of study as potential biomarkers of treatment-related toxicity and tumor response to treatment among other clinical secondary outcomes (e.g. surgical complications, overall survival). OUTLINE: Patients choose which arm (I or II) they would like to participate in, depending upon availab…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age ≥ 18 years * Diagnosed with: potentially resectable non small cell lung cancer (NSCLC) stage (9th edition: IB-IIIB) * Intent to receive surgery following neoadjuvant systemic therapy from the Ohio State University Comprehensive Cancer Center (OSUCCC) Thoracic Oncology Clinic * Patients who are at least 6 weeks out of the surgery date are eligible to participate * Willingness to participate and adhere to the study intervention program * Ability to understand and willingness to sign an informed consent document Exclusion Criteria: * Prisoners are excluded from partic…
Interventions
- ProcedureBiospecimen Collection
Undergo blood sample collection
- OtherExercise Intervention
Complete exercises at home
- OtherExercise Intervention
Receive portable exercise peddler and resistance bands
- OtherExercise Intervention
Complete assigned exercises
- OtherInternet-Based Intervention
Receive access to the BeFitMe application
- ProcedurePhysical Therapy
Complete physical therapy sessions
- BehavioralRelaxation Technique
Complete progressive muscle relaxation
- OtherSurvey Administration
Ancillary studies
- OtherText Message-Based Navigation Intervention
Receive motivational text messages
Location
- Ohio State University Comprehensive Cancer CenterColumbus, Ohio