The Effect of Static Magnetic Fields on Neuroinflammation in Migraine
Marco Loggia
Summary
We are conducting this research in individuals with migraines to find out if a daily magnet helmet application could alter migraine-related brain inflammation. Outcomes will be assessed through examining any changes in Translocator Protein (TSPO) binding on Positron Emission Tomography-Computed Tomography (PET-CT) imaging both before and after the magnet helmet intervention period. Additionally, patient-reported migraine symptoms will be measured using validated questionnaires administered during the four-week pre- and post- intervention monitoring periods.
Description
This pilot study is designed to evaluate the preliminary biological signals associated with a non-drug, at-home, self-administered intervention in individuals with migraine. This study will last approximately 11 weeks and involve three in-person visits to the Massachusetts General Hospital Charlestown Navy Yard campus. The first visit will involve screening tests to determine eligibility. The second and third visits will both be imaging visits, where participants would undergo PET-CT scans, as well as additional Magnetic Resonance Imaging (MRI) scan. These scan visits will be performed before…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Between 18 and 65 years of age. 2. Migraine diagnosis must come from a neurologist or other qualified MD, and the diagnosis must meet International Classification of Headache Diagnosis, Version 3 (ICHD-3) beta criteria for migraine according to either of the categories: ICHD-3 beta 1.1: Migraine without aura ICHD-3 beta 1.2: Migraine with aura 3. The frequency of migraine attacks must be at least 4 migraine-days per month. 4. The duration of the disease must be of at least one year. 5. Willingness to adhere to daily intervention sessions and complete study procedure…
Interventions
- DeviceStatic magnetic helmet
Participants will wear a static magnetic helmet for 20 minutes daily during a 21-day intervention period
Location
- A.A. Martinos Center for Biomedical ImagingCharlestown, Massachusetts