A Single Center Diagnostic Study of Endothelial Inflammation and Health Status in Patients With Ischemia and Nonobstructive Coronary Arteries (INOCA)

Summary

The purpose of this study is to evaluate coronary artery and peripheral vein vascular endothelial profiles in patients with ischemia with non-obstructive coronary arteries (INOCA) who undergo coronary function testing (CFT). The aims are: (1) Evaluate coronary artery endothelial profiles and associations with coronary microvascular dysfunction (CMD) in INOCA. (2) Assess brachial vein endothelial cell profiles in patients with INOCA and associations with CMD, and (3) Characterize relationships between endothelial signatures and anginal symptoms, functional status, and physical activity at baseline and 1-year follow-up.

Eligibility

Age range

18+ years

Sex

All

Healthy volunteers

No

Interventions

• Procedure
  Invasive coronary angiography

  Participant will undergo invasive coronary angiography as clinically indicated (standard of care).

• Procedure
  Coronary Artery Endothelial Cell Sampling

  Endothelial cells will be obtained from clinical coronary guidewires after retrieval from the guide catheter.

• Device
  Fitbit

  Wearable activity monitoring device that measures physical activity based on the number of steps per day. The device also tracks sleep efficiency (exploratory) through a proprietary algorithm, and other health metrics. Daily step count and heart rate are recorded on the wearable device.

• Diagnostic Test
  Invasive coronary function testing

  Participants will undergo invasive coronary function testing as clinically indicated (standard of care).

Location