Skin Substitutes Versus Secondary Intention Healing After Mohs Micrographic Surgery
Baylor Research Institute
Summary
The purpose of this study is to compare two ways of caring for wounds after Mohs micrographic surgery (MMS) for skin cancer using skin substitutes and secondary intention healing, to determine which option leads to better healing after Mohs surgery.
Description
This is a randomized-controlled trial comparing two ways of caring for wounds after Mohs micrographic surgery for skin cancer: skin substitutes, which are special wound-healing materials that may help wounds heal, and secondary intention healing, a common method in which wounds are allowed to heal on their own. This research is being done because we do not yet know which option leads to better healing after Mohs surgery. Patients will be randomized into one of two groups and receive either the skin substitute or undergo secondary intention healing.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults 18 and older undergoing Mohs micrographic surgery * Wounds deemed clinically appropriate for secondary intention healing * Ability to adhere to daily wound care and follow-up visits * Willingness to consent to standardized medical photography Exclusion Criteria: * Wounds requiring flap or graft reconstruction for structural/functional reasons * Active wound infection at time of reconstruction * Known allergy to any component of the skin substitute * Severe immunosuppression in which either approach may pose undue risk
Interventions
- BiologicalSkin Substitute
Application of a commercially available skin substitute (e.g., acellular dermal matrix or fish-skin xenograft) to the wound base followed by routine daily wound care.
- BiologicalSecondary Intention Healing
Standard secondary intention healing with daily wound care only.
Location
- Baylor University Medical CenterDallas, Texas