A Clinical Trial to Study the Effect of a Single Dose of Ulonivirine on the Pharmacokinetics of Methadone

Merck Sharp & Dohme LLC

Summary

This study is designed to determine the effect of ulonivirine (MK-8507) on methadone in the body. Participants will take methadone alone and then methadone with ulonivirine to see if ulonivirine changes how the body processes methadone.

Eligibility

Age range: 18–65 years
Sex: All
Healthy volunteers: Yes

Detailed criteria

Inclusion Criteria The main Inclusion Criteria include but are not limited to: * Is in good health * Has a body mass index (BMI) between \>18 and ≤40 kg/m\^2 * Is reliably participating in a methadone maintenance program for at least 2 months prior to Day 1 and is on a documented stable dose of methadone for at least 14 days prior to Day 1 Exclusion Criteria The main Exclusion Criteria include but are not limited to: * Has a history of cancer (malignancy) * Has a history of significant multiple and/or severe allergies, or has had an anaphylactic reaction or significant intolerability to p…

Interventions

Drug
Ulonivirine
Oral Tablet
Drug
Methadone
Oral (per local guidelines)

Location

Pinnacle Research Group ( Site 0002)
Anniston, Alabama
256-236-0055

A Clinical Trial to Study the Effect of a Single Dose of Ulonivirine on the Pharmacokinetics of Methadone

Summary

Eligibility

Interventions

Location

Run this study?

Details

Conditions