Light Therapy to Improve Sleep in Veterans With TBI: Sleep-active Biomarkers and Glymphatic Function
Oregon Health and Science University
Summary
This is a clinical trial designed to examine how improved sleep through morning bright light therapy is improving downstream key physiologic processes related to brain health, i.e., mitochondrial function, systemic inflammation, and glymphatic function. All proposed methodology is already approved in other IRB applications.
Eligibility
- Age range
- 18–89 years
- Sex
- All
- Healthy volunteers
- No
All subjects must: 1. Male and female; any race; 18-89 years of age. 2. Be English speaking.\* 3. Be accessible via phone. 4. Be non-decisionally impaired. Determined by assessing the subject's ability to verbalize their understanding of the protocol back to us during the informed consent process. 5. Not have a history of macular degeneration. 6. Not have a history of bipolar disorder. 7. Not be currently using a lightbox or a negative ion generator. 8. Not be a shift worker. 9. Have a documented history of TBI via the Head Trauma Events Characteristics (HTEC) or OHIO conducted in accordance…
Interventions
- DeviceMorning Bright Light Therapy
Exposure to bright light shortly after waking.
- DeviceNegative Ion Generator Therapy
Exposure to negative ions shortly after waking.
Location
- Oregon Health and Science UniversityPortland, Oregon